条件を付加する。利用者は事前に寄託者の提供承諾書を得る。<br>* The RIKEN BRC shall maintain, store, multiply and distribute the BIOLOGICAL RESOURCE in Japan only. <br>* Before any access to the biological resource, the Recipient will sign (as well as his/her administrative authority) the enclosed form to be sent to the Depositor (Institute Pasteur). <br>* Prior to applications for a patent, or intellectual property or other rights based on the results of research using the BIOLOGICAL RESOURCE, the recipient shall discuss such applications with the DEPOSITOR. Use of the BIOLOGICAL RESOURCE shall be a collaborative research with the DEPOSITOR. The DEPOSITOR requires to be co-owner for the inventions or other intellectual property generated by using the BIOLOGICAL RESOURCE. C（3〜6か月） Tambaleante(tbl)はOrleans-La SourceのCNRS繁殖センターでDW/J-Pas系統に起こった劣性の自然突然変異マウスである。パスツール研究所 (Institut Pasteur, Paris, Cedex 15, France) のゲネ博士により維持されている。1997年に理化学研究所ライフサイエンス筑波研究センター実験動物室に導入。以後、コンベンショナル施設で6代兄妹交配により維持。体外受精によりSPF施設へ導入後、2003年７月現在、兄妹交配F18代。 Necessary documents for ordering:<ol><li>Approval form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_6.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_d.docx">English</A>)</li><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li></ol> 毛色遺伝子型A/A, ln/lnで淡褐色の被毛を有する系統である。常染色体性劣性遺伝子による小脳性の歩行異常を示す。直進歩行が困難でその様子があたかも「泥酔した人」に似ているので、その意味のスペイン語tambaleanteがその変異遺伝子名にあてられた。離乳後に症状が現れ、加齢とともに症状は顕著となる。組織学的には生後２ヶ月以降、急速に小脳のプルキニエ神経細胞が変性脱落する。ホモの雄は繁殖可能。ホモの雌は繁殖可能だが系統維持には不適。ホモの雄とヘテロの雌を交配して系統維持する。 Jean-Louis Guenet Jean-Louis Guenet Coat color gene: A/A, ln/ln. The homozygous mutant mice exhibit neurological symptom characteristics to the cerebellar mutant, can not walk straight after weaning. The gene name Tambaleante comes from Spanish word meaning a drunken person with awkward behavior. Histologically Purkinje cells in the cerebellar cortex degenerate rapidly after 2 months of age. Both homozygous females and males can breed, but the females are poor breeders. The strain is maintained by sister-brother mating between heterozygous females and homozygous males. Coat color gene: A/A, ln/ln. The homozygous mutant mice exhibit neurological symptom characteristics to the cerebellar mutant, can not walk straight after weaning. The gene name Tambaleante comes from Spanish wordmeaning a drunken person with awkward behavior. Histologically Purkinje cells in the cerebellar cortex degenerate rapidly after 2 months of age.Both homozygous females and males can breed, but the females are poor breeders. The strain is maintained by sister-brother mating between heterozygous females and homozygous males. Tambaleante (tbl) mutant was occurred in the DW/J-Pas background, and foundin the CNRS breeding center of Orleans-La Source. This mutation isautosomal recessive, affecting primarily Purkinje cells in the cerebellar cortex. The mutant has been maintained in the Institut Pasteur, Paris,Cedex, France by Dr. Guenet J-L. The mutant mice imported to Experimental Animal Research Division, Life Science Tsukuba Research Center, RIKEN in 1997. The mice were sib-mated for 6 generations in the conventional facility. Then, the mice were rederived by in vitro fertilization and embryo transfer into the SPF facility, followed by sib-mating for 18 generations (July, 2003). Tambaleante(tbl)はOrleans-La SourceのCNRS繁殖センターでDW/J-Pas系統に起こった劣性の自然突然変異マウスである。パスツール研究所 (Institut Pasteur, Paris, Cedex 15, France) のゲネ博士により維持されている。1997年に理化学研究所ライフサイエンス筑波研究センター実験動物室に導入。以後、コンベンショナル施設で6代兄妹交配により維持。体外受精によりSPF施設へ導入後、2003年７月現在、兄妹交配F18代。, The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. * The RIKEN BRC shall maintain, store, multiply and distribute the BIOLOGICAL RESOURCE in Japan only. <br>* Before any access to the biological resource, the Recipient will sign (as well as his/her administrative authority) the enclosed form to be sent to the Depositor (Institute Pasteur). <br>* Prior to applications for a patent, or intellectual property or other rights based on the results of research using the BIOLOGICAL RESOURCE, the recipient shall discuss such applications with the DEPOSITOR. Use of the BIOLOGICAL RESOURCE shall be a collaborative research with the DEPOSITOR. The DEPOSITOR requires to be co-owner for the inventions or other intellectual property generated by using the BIOLOGICAL RESOURCE. DW/JPas-Herc1<tbl>/PasRbrc Tambaleante (tbl) mutant was occurred in the DW/J-Pas background, and foundin the CNRS breeding center of Orleans-La Source. This mutation isautosomal recessive, affecting primarily Purkinje cells in the cerebellar cortex. The mutant has been maintained in the Institut Pasteur, Paris,Cedex, France by Dr. Guenet J-L. The mutant mice imported to Experimental Animal Research Division, Life Science Tsukuba Research Center, RIKEN in 1997. The mice were sib-mated for 6 generations in the conventional facility. Then, the mice were rederived by in vitro fertilization and embryo transfer into the SPF facility, followed by sib-mating for 18 generations (July, 2003). Institut Pasteur Institut Pasteur DW/Pas-<tbl> DW/Pas-<tbl> RBRC00188 DW/Pas-tbl C (3-6 months) false